Key points:

Chicago Department of Public Health (CDPH) has identified a steady increase in mpox cases beginning end of June 2025. During the first week of August 2025, 10 mpox cases were diagnosed compared to two cases the week prior.
Between June 1- August 18, 2025, 30 cases of mpox have been reported to CDPH. Of the 30 cases, 97% of cases (29 cases) were among symptomatic males. The majority of cases were unvaccinated; however, 10 of 30 cases (36%) were fully vaccinated against mpox.
No cases of clade I mpox have been reported in Chicago thus far.
Healthcare providers are urged to remain diligent in screening for mpox, and vaccinating people at risk.

For the most up-to-date mpox case summary, please view our CDPH mpox dashboard.

For providers:

Suspect or confirmed cases of mpox must be reported within 24 hours. Please report via the Illinois Disease Surveillance System (IDSS) or please call 311 to speak to a CDPH medical director (or 312-744-5000 from outside the City of Chicago).
If your organization would like to order mpox vaccine from CDPH, please fill out the order form here: https://redcap.link/2025mpoxvaxorderform

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