Summary and Action Items

Chicago Department of Public Health (CDPH) has identified a resurgence of cases of mpox (formerly monkeypox).
From April 17th-May 5th 2023, 12 confirmed and one probable case of mpox were reported to CDPH. All cases were among symptomatic men. Nine (69%) of 13 cases were among men who were fully vaccinated for mpox.
Transmission of mpox continues locally and disproportionately affects the same populations affected by Sexually Transmitted Infections (STIs) and human immunodeficiency virus (HIV).
Healthcare providers are urged to remain diligent in screening and vaccinating at risk populations.
Vaccination is an important tool in stopping the spread of mpox, although vaccine-induced immunity is not complete. People who are vaccinated should continue to avoid close, skin-to-skin contact with someone who has mpox.
JYNNEOS is a 2-dose vaccine approved for the prevention of mpox and smallpox. All eligible Chicagoans should receive both doses of the vaccine for the best protection against mpox. The second dose should be given 4 weeks after the first dose. If more than 35 days has elapsed since the first dose was given, administer the second dose as soon as possible. Vaccine boosters are not recommended at this time.
CDPH encourages healthcare providers to adopt a syndemic approach to addressing mpox and including incorporating mpox, STI and HIV screening, treatment and prevention into existing sexual health services.

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