KEY MESSAGES AND ACTION ITEMS:

Given the recent surge in COVID-19 infections across Chicago and Illinois, clinicians should familiarize themselves with the clinical presentation, evaluation, management, and reporting requirements for Multisystem Inflammatory Syndrome in Children (MIS-C).
MIS-C is a rare but severe post-infectious sequela of COVID-19 in children marked by fever, elevated inflammatory markers, and severe illness involving two or more organ systems.
In Chicago and nationally1, increases in MIS-C cases are seen 3 to 4 weeks following surges in COVID-19 cases in the community, reflecting the delay between initial SARS-CoV-2 infection and subsequent inflammatory response. It often occurs after asymptomatic or mild infections, so a lack of known exposure or infection following periods of high local transmission should not rule out the diagnosis.
Follow the MIS-C Clinical Pathway for cases of suspected MIS-C, including timely transfer to intensive care.
Report MIS-C in Chicago residents to CDPH by following instructions on the HAN page: https://www.chicagohan.org/covid-19/mis-c OR follow the two steps below:

Fill out the MIS-C case report form link available at https://redcap.link/misc_afm and upload it confidentially through the same portal (here).
Enter suspect MIS-C cases into the COVID-19 I-NEDSS module – subsection “Multisystem Inflammatory Syndrome”.

See MIS-C Guidanc attachment for full details. MIS-C Annual Report also attached.

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